Manuscripts

The following information for US healthcare professionals includes links to Apellis-sponsored clinical trials that have been published in peer reviewed journals. The list of publications below may contain information about doses, uses, formulations and populations different from product labeling or contain information about investigational compounds or uses not approved by a regulatory authority. The following list of publications is not comprehensive or exhaustive as to any particular topic. Apellis does not suggest or recommend the use of its products in any manner other than as described in the Prescribing Information. Please refer to the product’s Full Prescribing Information.

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Paroxysmal nocturnal hemoglobinuria (PNH)

  • Comparative effectiveness of pegcetacoplan versus ravulizumab in patients with paroxysmal nocturnal hemoglobinuria previously treated with eculizumab: a matching-adjusted indirect comparison
    • Rachel H. Bhak, Nikita Mody-Patel, Scott B. Baver, Colin Kunzweiler, Christopher W. Yee, Sanjana Sundaresan, Natalia Swartz, Mei Sheng Duh, Sangeeta Krishnan & Sujata P. Sarda (2021) Comparative effectiveness of pegcetacoplan versus ravulizumab in patients with paroxysmal nocturnal hemoglobinuria previously treated with eculizumab: a matching-adjusted indirect comparison, Current Medical Research and Opinion, 37:11, 1913-1923, DOI: 10.1080/03007995.2021.1971182
  • Real-World Healthcare Resource Utilization (HRU) and Costs of Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Receiving Eculizumab in a US Population
    • Cheng WY, Sarda SP, Mody-Patel N, et al. Real-World Healthcare Resource Utilization (HRU) and Costs of Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Receiving Eculizumab in a US Population. Adv Ther. 2021;38(8):4461-4479. doi:10.1007/s12325-021-01825-4
  • Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria
    • Hillmen P, Szer J, Weitz I, et al. Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria. N Engl J Med. 2021;384(11):1028-1037. doi:10.1056/NEJMoa2029073
  • C3 inhibition with pegcetacoplan in subjects with paroxysmal nocturnal hemoglobinuria treated with eculizumab
    • de Castro C, Grossi F, Weitz IC, et al. C3 inhibition with pegcetacoplan in subjects with paroxysmal nocturnal hemoglobinuria treated with eculizumab. Am J Hematol. 2020;95(11):1334-1343. doi:10.1002/ajh.25960
  • Paroxysmal nocturnal hemoglobinuria: patient journey and burden of disease
    • Bektas M, Copley-Merriman C, Khan S, Sarda SP, Shammo JM. Paroxysmal nocturnal hemoglobinuria: patient journey and burden of disease. J Manag Care Spec Pharm. 2020;26(12-b Suppl):S8-S14. doi:10.18553/jmcp.2020.26.12-b.s8

Oncology

  • Inside-Out of Complement in Cancer
    • Kolev M, Das M, Gerber M, Baver S, Deschatelets P and Markiewski MM (2022) Inside-Out of Complement in Cancer. Front. Immunol. 13:931273. doi: 10.3389/fimmu.2022.931273

Geographic Atrophy (GA)

  • Humanistic and Economic Burden of Geographic Atrophy: A Systematic Literature Review
    • Sarda, Sujata & Heyes, Anne & Bektas, Meryem & Thakur, Tanvee & Chao, Wendy & Intorcia, Michele & Wronski, Samantha & Jones, Daniel. (2021). Humanistic and Economic Burden of Geographic Atrophy: A Systematic Literature Review. Clinical ophthalmology (Auckland, N.Z.). 2021. 4629–4644. 10.2147/OPTH.S338253.
  • Characterizing New-Onset Exudation in the Randomized Phase 2 FILLY Trial of Complement Inhibitor Pegcetacoplan for Geographic Atrophy
    • Wykoff CC, Rosenfeld PJ, Waheed NK, et al. Characterizing New-Onset Exudation in the Randomized Phase 2 FILLY Trial of Complement Inhibitor Pegcetacoplan for Geographic Atrophy. Ophthalmology. 2021;128(9):1325-1336. doi:10.1016/j.ophtha.2021.02.025
  • Impact of Baseline Characteristics on Geographic Atrophy Progression in the FILLY Trial Evaluating the Complement C3 Inhibitor Pegcetacoplan
    • Steinle NC, Pearce I, Monés J, et al. Impact of Baseline Characteristics on Geographic Atrophy Progression in the FILLY Trial Evaluating the Complement C3 Inhibitor Pegcetacoplan. Am J Ophthalmol. 2021;227:116-124. doi:10.1016/j.ajo.2021.02.031
  • Complement C3 Inhibitor Pegcetacoplan for Geographic Atrophy Secondary to Age-Related Macular Degeneration: A Randomized Phase 2 Trial
    • Liao DS, Grossi FV, El Mehdi D, et al. Complement C3 Inhibitor Pegcetacoplan for Geographic Atrophy Secondary to Age-Related Macular Degeneration: A Randomized Phase 2 Trial. Ophthalmology. 2020;127(2):186-195. doi:10.1016/j.ophtha.2019.07.011

C3G/IC-MPGN

  • Novel Complement Therapeutics in Development as Potential Treatment for Renal Disease
    • Kelleher C, Kocinsky H. Novel Complement Therapeutics in Development as Potential Treatment for Renal Disease. Adv Chronic Kidney Dis. 2020;27(2):95-103. doi:10.1053/j.ackd.2020.02.006

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